Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors

Recruiting now

Conditions studied: Brain Tumor, Primary, Brain Tumor - Metastatic

In brief

The goal of this observational study is to characterize the circulating leukocyte profile and the immune T cells distribution within the tumor in patients with malignant brain tumors and to correlate these findings with the oncological outcome. Participants will be subjected to blood sampling before surgery and for 12 months of follow-up. Additional sampling and analysis will be performed on tumor samples.

Key facts

Study ID

NCT05831631

Run by

Pietro Mortini, MD, Prof.

People needed

200

Starts

2022-08-01

Expected to finish

2029-08-01

Last updated by the study team

2025-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years)
• Able to express informed consent
• With primary or secondary malignant brain tumor
• Requiring neurosurgical treatment (radiosurgery, stereotactic biopsy, surgery)

You may not qualify if…

• Patients who do not meet inclusion criteria.

Where it is running

• IRCCS San Raffaele Scientific Institute — Milan, Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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