Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Cognitive Dysfunction, Mobility Limitation, Frail Elderly

In brief

Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

Key facts

Study ID

NCT05830942

Run by

University of Florida

People needed

120

Starts

2024-04-15

Expected to finish

2027-04-30

Last updated by the study team

2026-06-03

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 65+
• Objective executive function decline, based on standardized cognitive assessments.
• Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
• Ability to walking independently for 6 minutes (use of cane permitted)

You may not qualify if…

• Major cognitive disorder that interferes with independence
• Percentile score less than 10th percentile on standardized cognitive assessments
• Medications that are thought to influence tDCS neuroplasticity.
• Contraindications to tDCS or MRI.

Where it is running

• University of Florida — Gainesville, Florida, United States (enrolling)
• Brooks Rehabilitation — Jacksonville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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