Study of Anlotinib in Patients With Advanced Medullary Thyroid Carcinoma

Recruiting now · Phase 4

Conditions studied: Medullary Thyroid Cancer

In brief

This is a real world study aiming to observe the efficacy and safety of Anlotinib capsules in patients with advanced medullary thyroid carcinoma, and to summarize the treatment experience in a broad population of patients.

Key facts

Study ID

NCT05830500

Run by

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

People needed

360

Starts

2023-06-19

Expected to finish

2028-12-01

Last updated by the study team

2023-07-25

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients voluntarily joined the study, signed the informed consent, and had good compliance;
• Patients ≥18 years of age (at the time of signing the informed consent); Eastern Cooperative Oncology Group Performance Status (ECOG-PS) score: 0-2; Expected survival of more than 3 months;
• Patients were pathologically confirmed as inoperable locally advanced or metastatic medullary thyroid carcinoma (MTC), possessing imaging or clinical evidence of disease progression within the first 14 months of enrollment;
• Having at least one measurable lesion (assessed by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1);
• Major organ functions meet the following criteria within 7 days prior to the treatment:
• Blood routine examination shall meet the following standards (no transfusion within 14 days) :
• Hemoglobin (Hb) ≥85g/L;
• Absolute Neutrophil Count (ANC) ≥1.5×109/L;
• Platelet (PLT) ≥80×109/L；
• Biochemical examination shall meet the following standards:
• Total bilirubin (TBIL) ≤1.5 times the upper limit of normal (ULN);
• Alanine transferase (ALT) and Aspartate transferase (AST) ≤2.5×ULN; If accompanied by liver metastasis, ALT and AST ≤5×ULN；
• Serum creatinine (Cr) ≤1.5×ULN or Creatinine clearance rate (CCr) ≥60ml/min；
• Female patients of reproductive age should agree that birth control (such as intrauterine device, birth control pills, or condoms) must be used during the study period until six months after completion; Having a negative serum pregnancy test within 7 days prior to study enrollment, and must be non-lactating; Male patients should agree to use contraception during the study period until six months after the end of the study.

You may not qualify if…

• Complicated diseases and history:
• Patients currently have or had other malignancies within 3 years. Patients with the following two conditions can be included in the group: Continuous 5-year disease-free survival (DFS) was achieved for other malignancies treated with a single operation. Cured cervical carcinoma in situ, non-melanoma skin cancer, and superficial bladder tumors [Ta (non-invasive tumor), Tis (carcinoma in situ) and T1 (the tumor infiltrates the basal membrane)];
• Major surgical treatment, open biopsy, or significant traumatic injury were received within 28 days before the beginning of the treatment;
• Subjects with any severe and/or uncontrolled disease, including:
• Having ≥ grade 2 myocardial ischemia or myocardial infarction or arrhythmia (including QTc ≥450ms (male), QTc ≥470ms (female) and ≥ grade 2 congestive heart failure (classified by New York heart association, NYHA));
• Active or uncontrolled severe infection (≥ Common Terminology Criteria for Adverse Events (CTC AE) 2 grade of infection);
• Renal failure requiring hemodialysis or peritoneal dialysis;
• Patients with concomitant diseases that, in the investigator's judgment, may seriously endanger patients' safety or may interfere with the completion of the study, or are deemed unsuitable for inclusion for other reasons.
• Patients who have previously used anlotinib hydrochloride capsules or similar Vascular Endothelial Growth Factor- Tyrosine Kinase Inhibitor (VEGFR-TKI) small molecule drugs, such as vandetanib, cabozantinib, lenvatinib, sunitinib, sorafenib, etc.;

Where it is running

• Zhejiang Provincial People's Hospital — Hangzhou, Zhejiang, China (enrolling)
• Beijing Tongren Hospital Affiliated to Capital Medical University — Beijing, Beijing Municipality, China (enrolling)
• Gansu Cancer Hospital — Lanzhou, Gansu, China (enrolling)
• Liaoning Cancer Hospital and Institute — Shenyang, Liaoning, China (enrolling)
• The First Affiliated Hospital of Xi'an Jiaotong University — Xi’an, Shanxi, China (enrolling)
• Tianjin People's Hospital — Tianjin, Tianjin Municipality, China (enrolling)
• The First Affiliated Hospital of Kunming Medical University — Kunming, Yunnan, China (enrolling)
• The First Affiliated Hospital of Hebei North University — Shijiazhuang, Hebei, China (enrolling)
• Tianjin Cancer Hospital — Tianjin, Hebei, China (enrolling)
• Henan Cancer Hospital — Zhengzhou, Henan, China (enrolling)
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China (enrolling)
• Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• Hubei Cancer Hospital — Wuhan, Hubei, China (enrolling)
• Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University — Nanjing, Jiangsu, China (enrolling)
• Jiangsu North People's Hospital — Yangzhou, Jiangsu, China (enrolling)
• Guangxi Zhuang Autonomous Region Cancer Hospital (Affiliated Cancer Hospital of Guangxi Medical University) — Nanning, Guangxi, China
• Hunan Cancer Hospital — Changsha, Hunan, China
• Shanxi Provincial Tumor Hospital — Xi’an, Shanxi, China
• Anhui Provincial Cancer Hospital — Hefei, Anhui, China

Full record on ClinicalTrials.gov

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