Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy
Running, not enrolling
Conditions studied: Gender Dysphoria, Transgender
In brief
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2. Determine presence and number of germ cells (sperm precursors) in the patients' testicular tissue. 3. Develop next generation cell- and tissue-based therapies for preserving fertility and treating infertility.
Key facts
- Study ID
- NCT05829928
- Run by
- University of Pittsburgh
- People needed
- 150
- Starts
- 2019-05-09
- Expected to finish
- 2029-05-01
- Last updated by the study team
- 2026-07-09
Who can join
Age: 9 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Category 1 participants must have all criteria listed below:
- Patient with testes over the age of 9
- Diagnosed with gender dysphoria; currently on or imminently planning to start gender affirming treatment (hormone blockers or gender-affirming hormones)
- Have a clinical referral for fertility preservation from their primary care physician
- Unwilling to undergo natal puberty or, for patients who have gone through puberty, unwilling to discontinue hormone suppression and/or hormone replacement therapy.
- Category 2 participants only fall into this category if they are undergoing gender-affirming surgery. They must have all criteria listed below:
- Patient is 18+ years old
- Diagnosed with gender dysphoria
- Unwilling to undergo natal puberty, or for patients who have gone through puberty, be unwilling to discontinue hormone suppression and/or sex steroid (estrogen) therapy.
- Will be undergoing gender affirming surgery that involves removal of the testes.
You may not qualify if…
- Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
- Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.
Where it is running
- Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.