Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Critical Illness, New Onset Atrial Fibrillation

In brief

A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.

Key facts

Study ID

NCT05829317

Run by

Dr. Stephanie Sibley

People needed

200

Starts

2023-08-20

Expected to finish

2028-07-01

Last updated by the study team

2025-09-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years;
• Admitted to an ICU with one or more of the following:
• Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (>10L/min) or invasive mechanical ventilation with an expected duration >24 hours for respiratory failure (hypercarbic or hypoxic)
• Vasopressor or inotropic support with an expected duration of >24 hours
• Cardiac arrest
• Continuous cardiac monitoring.

You may not qualify if…

• Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for >18 hours
• Receiving IMV for airway protection only (for example, isolated head trauma)
• Active atrial fibrillation at the time of enrolment
• On oral or continuous infusion of Amiodarone
• Unlikely to survive >24 hours or palliative patients
• Cardiac surgery patients
• Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
• Patients receiving dialysis
• Positive pregnancy test (females <50 years old)
• Previously enrolled in this trial
• Treating physician refuses enrollment

Where it is running

• Kingston Health Sciences Centre — Kingston, Ontario, Canada (enrolling)
• St Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada
• The Ottawa Hospital - General Campus — Ottawa, Ontario, Canada
• The Ottawa Hospital - Civic Campus — Ottawa, Ontario, Canada

Full record on ClinicalTrials.gov

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