A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors

Withdrawn before enrolling · Phase 1

Conditions studied: Advanced Solid Tumor, Metastatic Solid Tumor

In brief

This is a Phase 1 study to evaluate the potential drug-drug interaction (DDI) effect of repotrectinib on certain drug transporters in patients with advanced cancer.

Key facts

Study ID

NCT05828303

Run by

Turning Point Therapeutics, Inc.

People needed

0

Starts

2024-11-15

Expected to finish

2025-11-30

Last updated by the study team

2025-04-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Gabrail Cancer Research Center — Canton, Ohio, United States
• Local Institution - 2101 — Canton, Ohio, United States
• Local Institution - 2119 — Westmead, New South Wales, Australia
• Local Institution - 2126 — Botafogo, Rio de Janeiro, Brazil
• Local Institution - 2132 — Porto Alegre, Rio Grande do Sul, Brazil
• Local Institution - 2134 — Porto Alegre, Rio Grande do Sul, Brazil
• Local Institution - 2130 — São Paulo, São Paulo, Brazil
• Local Institution - 2108 — São Paulo, Brazil
• Local Institution - 2123 — Bordeaux, France
• Local Institution - 2122 — La Tronche, France
• Local Institution - 2117 — Marseille, France
• Local Institution - 2115 — Nantes, France
• Local Institution - 2121 — Poitiers, France
• Local Institution - 2136 — Rennes, France
• Local Institution - 2120 — Saint-Herblain, France
• Local Institution - 2135 — Milan, MI, Italy
• Local Institution - 2116 — Rozzano, MI, Italy
• Local Institution - 2111 — Perugia, PG, Italy
• Local Institution - 2104 — Aviano, PN, Italy
• Local Institution - 2103 — Verona, VR, Italy
• Local Institution - 2114 — Naples, Italy
• Local Institution - 2124 — Barcelona, B, Spain
• Local Institution - 2113 — Barcelona, B, Spain
• Local Institution - 2105 — Barcelona, B, Spain
• Local Institution - 2129 — Pozuelo de Alarcón, Madrid, Spain

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.