HFNC Compared With Facial Mask in Patients With Chest Trauma Patients
Recruiting now · Not applicable
Conditions studied: Chest Trauma, Hypoxia
In brief
Guidelines for noninvasive ventilation (NIV) recommend continuous positive airway pressure in patients with thoracic trauma who remain hypoxic . However, no any suggestion was applied for high flow nasal cannula (HFNC). Therefore, Our aim was to determine whether HFNC reduces intubation in severe trauma-related hypoxemia.
Key facts
- Study ID
- NCT05828030
- Run by
- National Taiwan University Hospital
- People needed
- 100
- Starts
- 2023-04-26
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-09-08
Who can join
Age: 20 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who have the following condition within 72 hours of chest trauma despite receiving standard nasal cannula oxygen therapy [≥10 L/min], are eligible for inclusion.
- severe hypoxemic respiratory failure [Arterial partial pressure of oxygen (PaO2)/fraction of inspired oxygen fraction(FiO2) <300 mmHg]
- with a respiratory rate >25 breaths/minute and difficulty breathing, or respiratory distress
- PaCO2 of 45 mmHg or higher (if the patient requires emergency surgery with endotracheal intubation and mechanical ventilation, the time of inclusion will be the start of the post-extubation period. (Note: For patients who receive emergency trauma surgery with endotracheal intubation and mechanical ventilation, the time of inclusion assessment will be 72 hours after extubation.)
You may not qualify if…
- Patients with a Glasgow Coma Scale less than 8 or severe brain injury.
- Patients with any contraindications to non-invasive ventilation, including acute gastrointestinal bleeding, upper airway obstruction, or hemodynamic instability.
- Facial trauma involving skull base fractures, facial bone fractures, or orbital floor fractures.
- Severe injuries involving the nasal sinuses.
- Patients with cervical spine injuries.
- Patients with increased intracranial pressure.
- Patients with facial, nasal, or airway structural abnormalities or surgery that prevents the use of appropriate nasal cannula.
- Patients after upper airway surgery.
- Patients who are unable to clearly express their willingness to sign informed consent.
Where it is running
- Department of Traumatology, National Taiwain University Hospital — Taipei, Taipei, Taiwan (enrolling)
- NTUH Hsin-Chu Branch; NTUH Yun-Lin Branch — Taipei, Taiwan, Taiwan (enrolling)
Full record on ClinicalTrials.gov
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