Study of mRNA-1010 Seasonal Influenza Vaccine in Adults

Completed · Phase 3

Conditions studied: Seasonal Influenza

In brief

This study includes 3 parts: Parts A, B, and C. The purpose of this study is to evaluate the immunogenicity and safety of mRNA-1010 seasonal influenza vaccine in adults.

Key facts

Study ID

NCT05827978

Run by

ModernaTX, Inc.

People needed

8411

Starts

2023-04-17

Expected to finish

2024-06-24

Last updated by the study team

2025-07-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Investigator has assessed that the participant understands and is willing and physically able to comply with protocol mandated follow up, including all procedures.
• For assigned females at birth and of childbearing potential: negative pregnancy test, adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to Day 1, and agreement to continue adequate contraception through 90 days following vaccine administration.
• Part A:
• At least 18 years of age inclusive, at the time of signing the informed consent form (ICF).
• Part B:
• At least 18 and <65 years of age, at the time of signing the ICF.
• Part C:
• At least 65 years of age or older, at the time of signing the ICF.

You may not qualify if…

• Participant has had close contact with someone with laboratory-confirmed influenza infection or with someone who has been treated with antiviral therapies for influenza (for example, Tamiflu®) within the past 5 days prior to Day 1.
• Participant is acutely ill or febrile (temperature ≥38.0℃elcius [100.4°Fahrenheit]) 72 hours prior to or at the Screening visit or Day 1. Participants meeting this criterion may be rescheduled within the 28-day screening window.
• Participant has a history of a diagnosis or condition that, in the judgment of the investigator, is clinically unstable or may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures.
• Reported history of congenital or acquired immunodeficiency, immunosuppressive condition or immune-mediated disease, asplenia, or recurrent severe infections.
• Participant has tested positive for influenza by local health authority-approved testing methods within 150 days (for Part A) or 180 days (for Parts B and C) prior to Day 1.
• Reported history of anaphylaxis or severe hypersensitivity reaction after receipt of mRNA vaccines or any components of the mRNA-1010 or influenza vaccines, including egg protein.
• Participant has received systemic immunosuppressants for >14 days in total within 180 days prior to Day 1 (for corticosteroids, ≥10 mg/day of prednisone or equivalent) or is anticipating the need for systemic immunosuppressive treatment at any time during participation in the study. Inhaled, nasal and topical steroids are allowed. Intra-articular and epidural steroid injections are not allowed within 28 days before and/or after study intervention dosing.
• Participant has received any vaccine authorized or approved by local health agency ≤28 days prior to study intervention dosing (Day 1) or plans to receive a vaccine authorized or approved by local health agency within 28 days before or after study intervention dosing.
• Participant has received a licensed seasonal influenza vaccine within 5 months (150 days) (for part A) or within 6 months (180 days) (for Parts B and C) prior to Day 1.
• Participant has participated in any investigational seasonal influenza vaccine study within12 months prior to Day 1.
• Participant is not aware whether they have received an influenza vaccine in the most recent influenza season (in the prior 12 months) (for Part A) or since September 2022 (for Parts B and C).
• Participant has donated ≥450 milliliters (mL) of blood products within 28 days prior to Day 1 or plans to donate blood products during the study.
• Note: Other inclusion and exclusion criteria may apply.

Where it is running

• North Alabama Research Center LLC — Athens, Alabama, United States
• Cullman Research Center — Cullman, Alabama, United States
• Medical Affiliated Research Center Inc — Huntsville, Alabama, United States
• Desert Clinical Research - CCT — Mesa, Arizona, United States
• Foothills Research Center - CCT — Phoenix, Arizona, United States
• Fiel Family &amp; Sports Medicine - PC - CCT — Tempe, Arizona, United States
• Noble Clinical Research — Tucson, Arizona, United States
• Baptist Health Center for Clinical Research — Little Rock, Arkansas, United States
• Velocity Clinical Research, Banning — Banning, California, United States
• Synexus Clinical Research US, Inc. - Cerritos — Cerritos, California, United States
• Marvel Clinical Research 002, LLC — Huntington Beach, California, United States
• Velocity Clinical Research — La Mesa, California, United States
• Pasadena Clinical Trials — Pasadena, California, United States
• Artemis Institute For Clinical Research LLC - Riverside - Headlands — Riverside, California, United States
• Peninsula Research Associates - CRN — Rolling Hills Estates, California, United States
• Optimal Research, LLC — San Diego, California, United States
• Acclaim Clinical Research — San Diego, California, United States
• Optimus Medical Group — San Francisco, California, United States
• Chase Medical Research LLC - Waterbury — Waterbury, Connecticut, United States
• Velocity Clinical Research - Hallandale Beach — Hallandale, Florida, United States
• Indago Research and Health Center — Hialeah, Florida, United States
• NeoClinical Reseaarch — Hialeah, Florida, United States
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
• Health Awareness Inc — Jupiter, Florida, United States
• Pinnacle Research Group — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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