Study of Product of Conception Derived From Ultrasound-guided Manual Vacuum Aspiration

Recruiting now

Conditions studied: Genetic Anticipation, Immunological Abnormalities

In brief

Early pregnancy loss is very common, approximately one in four women will experience a miscarriage in their lifetime. The etiology of pregnancy loss remains largely unknown, although genetic, anatomical, endocrinological and immunological abnormalities have been implicated. It is known that embryonic/fetal chromosomal aberrations contributed to approximately 50% of early pregnancy loss, among which 60-70% were aneuploidies, largely can be detected by the current gold standard karyotyping approach recommended by various international societies. However, the drawbacks of conventional karyotyping include the risk of culture failure, maternal cell contamination (MCC), limited detection resolution (5-10 Mb), and differential growth of specific cell lineages which could hinder the diagnosis of genetic abnormalities, particularly mosaicisms. Additional genetic factors beyond the resolution of karyotyping are not well studied.

Key facts

Study ID

NCT05825183

Run by

Chinese University of Hong Kong

People needed

100

Starts

2023-05-30

Expected to finish

2028-10-31

Last updated by the study team

2025-03-20

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women 18 years old or above
• Women with miscarriage or TOP who are suitable candidates for MVA
• first trimester miscarriage or TOP
• No fetal heart beat or TOP in those with CRL 25mm
• incomplete miscarriage or TOP with POG <5cm
• hemodynamically stable,
• tolerates well with speculum examination

You may not qualify if…

• Women who are not feasible for the MVA procedure
• cervical stenosis
• fibroid uterus >12 weeks in size
• known uterine malformation
• bleeding disorder
• clinically sepsis
• inability to tolerate pelvic examination
• History of psychological/ psychiatric problem
• Patient refusal

Where it is running

• Prince of Wales Hospital — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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