Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery

Recruiting now · Phase 4

Conditions studied: Pain, Postoperative

In brief

The goal of this clinical trial is to learn if there is a difference in morphine requirements in patients after upper extremity surgeries including shoulder arthroscopy. The main question it aims to answer is whether there is a difference between Interscalene brachial plexus blocks with the addition of buprenorphine, dexamethasone, and clonidine and the same block without the adjuvant.

Key facts

Study ID

NCT05824832

Run by

Loyola University

People needed

120

Starts

2023-02-28

Expected to finish

2026-06-30

Last updated by the study team

2025-03-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 18 years old
• Patients undergoing shoulder arthroscopy
• Patients willing to participate and sign informed consent

You may not qualify if…

• Severe COPD/other contraindication to general anesthesia
• Patient with a weight of less than 60 kg
• Dementia, not alert or oriented to person, place, or time
• Chronic pain patient with daily opioid use at home.
• Patient with allergy to local anesthetics
• Patient refusal
• Total shoulder arthroplasty
• Concomitant pain in different area from operative site.
• Pregnancy
• Patient with active infection on the injection sites for the blocks
• Patients unable or willing to understand or comply with the study protocol

Where it is running

• Loyola University Chicago — Maywood, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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