Use of SPECT-CT for Comparison of Dosimetry Methods in PSMA-targeted Radioligand Therapy (SPECTacular Study)
Status unconfirmed · Not applicable
Conditions studied: Metastatic Castration-resistant Prostate Cancer
In brief
The SPECTacular study will enroll patients who are already undergoing a FDA approved PSMA-targeted Radioligand treatment cycle. During each treatment cycle, patients will receive 5 additional SPECT/CT scans to investigate the limits of agreement between dosimetry (absorbed radiation dose) approximation methods and dosimetry using the triexponential fitting method.
Key facts
- Study ID
- NCT05823402
- Run by
- BAMF Health
- People needed
- 30
- Starts
- 2023-05-01
- Expected to finish
- 2024-10-31
- Last updated by the study team
- 2023-05-03
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Male, 18 years old or older
- Histologically or pathologically confirmed prostate adenocarcinoma without predominant small cell component.
- Patient is receiving PSMA-targeted Radioligand Therapy (PRLT) for treatment of PSMA-positive tumor and/or metastases of prostate cancer. Therapy may be FDA approved or investigational in nature under an approved clinical trial.
- Ability to lay flat on scanner for duration of SPECT-CT imaging studies (1-2 hours)
You may not qualify if…
- Assessment by the Investigator as unable or unwilling to comply with the requirements of the protocol.
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≥ 2
- All criteria which may preclude a PSMA-radioligand therapy using Lu-177 PSMA-617 or Lu-177 PSMA I\&T to be performed as per standardized guidelines and protocols laid down for these treatments and per decision by the treating physician.
Where it is running
- BAMF Health — Grand Rapids, Michigan, United States (enrolling)
Full record on ClinicalTrials.gov
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