Lenvatinib, Tislelizumab Combined with Gemcitabine and Cisplatin (GPLET) in the Treatment of Advanced Cholangiocarcinoma

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Advanced Cholangiocarcinoma

In brief

Cholangiocarcinoma (CCA) is a heterogeneous group of cancers arising from the epithelial cells of bile ducts. Because of highly aggressive malignancy, most of the patients are diagnosed at an advanced stage and lose the chance to undergo surgery. As more effective and novel chemotherapy, targeted therapies, and immunotherapy become available, multiple treatments can be chosen for the patients with advanced CCA. Cytotoxic cell death during tumor chemotherapy triggers antigen release and induces strong anti-tumor effects of T cells. Tyrosine kinase inhibitors (TKI) can reduce the expression of PD-L1 and inhibit Treg cell infiltration, and together with immune checkpoint inhibitors, they can relieve tumor immunosuppressive microenvironment. Therefore, the study aims to investigate the safety and efficacy of Lenvatinib, Tislelizumab combined with Gemcitabine plus Cisplatin (GPLET) in the treatment of advanced cholangiocarcinoma.

Key facts

Study ID

NCT05823311

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

80

Starts

2023-09-01

Expected to finish

2027-12-31

Last updated by the study team

2025-02-10

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically proven, unresectable advanced or metastatic cholangiocarcinoma patients.
• Expected survival period > 12 weeks.
• The World Health Organization (WHO) / ECOG physical status (PS) was 0 or 1.
• There was at least one target lesion that matched the RECIST 1.1 criteria at baseline.
• Not previously received immunotherapy, including but not limited to CTLA 4, PD-L1 or/and PD-1 inhibitors.
• Adequate organ and bone marrow function, defined as follows: Hemoglobin (Hb)≥9.0g/dL; Neutrophils (ANC) ≥ 1.5* 10\^9/L; Platelet (Pt) ≥ 50*10\^9/L; ALT≤2.5×ULN（Normal upper limit); AST≤2.5×ULN.
• Voluntary participation and signing of informed consent.

You may not qualify if…

• Active or previously documented autoimmune disease or inflammatory disease.
• Uncontrolled complications.
• History of other primary malignancies.
• Active infection.
• Women who are pregnant or breastfeeding.
• Patients with severe allergic history or specific constitution.
• Researchers consider it inappropriate to participate in the test.

Where it is running

• The Second Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (enrolling)

Full record on ClinicalTrials.gov

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