A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD
Recruiting now · Phase 1/Phase 2
Conditions studied: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 3, Huntington Disease
In brief
The goal of this first-in-human clinical trial is to assess the safety and tolerability of four doses of a new study drug called VO659 in people with genetic disorders called spinocerebellar ataxia type 1, type 3 or Huntington's disease. Another aim is to determine the concentrations of the study drug in the cerebral spinal fluid and blood after single and multiple doses. Study drug will be administered by lumbar intrathecal bolus injections.
Key facts
- Study ID
- NCT05822908
- Run by
- Vico Therapeutics B. V.
- People needed
- 68
- Starts
- 2023-02-14
- Expected to finish
- 2028-10-15
- Last updated by the study team
- 2025-08-28
Who can join
Age: 25 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rigshospitalet — Copenhagen, Denmark (enrolling)
- Centre Hospitalier Universitaire dÁngers — Angers, France (enrolling)
- CHU Gui de Chauliac Montpellier- Expert Center of Neurogenetic diseases, Department of Neurology — Montpellier, France (enrolling)
- Universtiry Hospitals Pitie Salpetriere - Charles foix - Paris — Paris, France (enrolling)
- Katholisches Klinikum Bochum — Bochum, Germany (enrolling)
- Deutsches Zentrum fur Neurodegenerative Erkrankungen (DZNE) — Bonn, Germany (enrolling)
- Universitatsklinikum Essen - Neurologie — Essen, Germany (enrolling)
- Universitatsklinikum Tübingen — Tübingen, Germany (enrolling)
- Meir Medical Center — Kfar Saba, Israel (enrolling)
- Sourmansky Medical Center — Tel Aviv, Israel (enrolling)
- Leiden University Medical Center LUMC — Leiden, Netherlands (enrolling)
- Radbout University Medical Centre — Nijmegen, Netherlands (enrolling)
- University College London Hospitals NHS Foundation — London, United Kingdom (enrolling)
- John Radcliffe Hospital — Oxford, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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