A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities

Completed · Phase 3

Conditions studied: Obesity, Overweight

In brief

The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without Type 2 Diabetes. The study will last around 74 weeks.

Key facts

Study ID

NCT05822830

Run by

Eli Lilly and Company

People needed

751

Starts

2023-04-21

Expected to finish

2024-11-13

Last updated by the study team

2025-11-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a body mass index (BMI) of ≥30 kilogram per square meter (kg/m²) or ≥27 kg/m² and previously diagnosed with at least one of the following weight related comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease
• Have a history of at least 1 unsuccessful dietary effort to lose body weight

You may not qualify if…

• Diabetes mellitus
• Change in body weight greater than 5 kg within 3 months prior to starting study
• Obesity induced by other endocrinologic disorders or monogenetic or syndromic forms of obesity
• History of pancreatitis
• Family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
• History of significant active or unstable major depressive disorder (MDD) or other severe psychiatric disorder within the last 2 years

Where it is running

• Cahaba Research — Birmingham, Alabama, United States
• Cahaba Research - Pelham — Pelham, Alabama, United States
• Southern California Dermatology, Inc. — Santa Ana, California, United States
• Encompass Clinical Research — Spring Valley, California, United States
• University Clinical Investigators, Inc. — Tustin, California, United States
• Velocity Clinical Research, Hallandale Beach — Hallandale, Florida, United States
• New Horizon Research Center — Miami, Florida, United States
• ForCare Clinical Research — Tampa, Florida, United States
• Rophe Adult and Pediatric Medicine/SKYCRNG — Union City, Georgia, United States
• Rocky Mountain Clinical Research — Idaho Falls, Idaho, United States
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
• L-MARC Research Center — Louisville, Kentucky, United States
• Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
• Prime Health and Wellness/SKYCRNG — Fayette, Mississippi, United States
• StudyMetrix Research — City of Saint Peters, Missouri, United States
• Palm Research Center Tenaya — Las Vegas, Nevada, United States
• Palm Research Center Sunset — Las Vegas, Nevada, United States
• Weill Cornell Medical College — New York, New York, United States
• PharmQuest — Greensboro, North Carolina, United States
• Lillestol Research — Fargo, North Dakota, United States
• Alliance for Multispecialty Research, LLC — Norman, Oklahoma, United States
• Tribe Clinical Research, LLC — Greenville, South Carolina, United States
• WR-Clinsearch, LLC — Chattanooga, Tennessee, United States
• The University of Texas Health Science Center at Houston — Bellaire, Texas, United States
• Dallas Diabetes Research Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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