Cognitive Decline Following Deep Brain Stimulation
Recruiting now
Conditions studied: Parkinson Disease, Movement Disorders
In brief
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.
Key facts
- Study ID
- NCT05822388
- Run by
- Medical University of South Carolina
- People needed
- 80
- Starts
- 2023-04-01
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects above 18 years of age
- Subjects who will undergo DBS surgery as part of their clinical care for PD
You may not qualify if…
- Uncorrected visual or hearing impairments, as indicated by self-report
- Individuals who are pregnant or expect to become pregnant during the course of the study
- Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
- COPD with oxygen dependence
- Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
- Non-PD Control Participants
- Inclusion Criteria:
- Subjects above 18 years of age
- Age matched to participants in PD group
- Exclusion Criteria:
- Diagnosis of Parkinsons Disease or other movement disorder
- Untreated neuropsychiatric disorders
- Uncorrected visual or hearing impairments, as indicated by self-report
- Individuals who are pregnant or expect to become pregnant during the course of the study
- Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
- COPD with oxygen dependence
- Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
Where it is running
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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