Determinants of Changes in Arterial Load Following Exercise
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Post-Exercise Hypotension
In brief
The goal of this study is to learn about how blood vessel dilation after exercise effects pulse wave reflection and influences the function of the heart in healthy young adults. The main question it aims to answer is: Are post-exercise decreases in reflected pulse waves due to a decrease in the stiffness of large arteries in the leg or an increase in leg blood flow? Participants will exercise on a stationary bicycle at a moderate intensity for 1 hour during two laboratory visits. Participants will take oral antihistamines to block post-exercise dilation at one visit, and they will take placebo pills at the other visit. At both visits, leg blood flow, pulse wave velocity, and heart function will be measured before exercise and for 120-minutes after exercise.
Key facts
- Study ID
- NCT05820243
- Run by
- University of Delaware
- People needed
- 25
- Starts
- 2023-05-12
- Expected to finish
- 2024-09-01
- Last updated by the study team
- 2023-11-28
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- healthy men and women
- sedentary or recreationally active
You may not qualify if…
- history of cardiovascular events or procedures
- stage 2 hypertension (BP: ≥140 systolic or ≥90 diastolic)
- metabolic syndrome
- renal disease
- chronic respiratory disease
- currently prescribed any cardiovascular medication
- current use of erythromycin and/ ketoconazole
- current pregnancy or breastfeeding -hormone replacement therapy-
- tobacco use
- musculoskeletal injury/disorder that would inhibit cycling exercise
- body mass index (BMI) <18.5 or >35kg/m\^2
- reduced kidney function (estimated glomerular filtration rate< 90ml/min/1.73 m\^2)
- daily use of fexofenadine and/or famotidine
Where it is running
- Department of Kinesiology and Applied Physiology, University of Delaware — Newark, Delaware, United States (enrolling)
Full record on ClinicalTrials.gov
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