Boosting Open-Label Placebo Effects in Acute Induced Pain in Healthy Adults
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Acute Pain
In brief
This study is to investigate the effect of open-label placebo (OLP) application on acute pain in an experimental model of acute pain (simulating wound pain: this installation will apply monophasic, rectangular electrical pulses of 0.5ms duration with alternating polarity at 2 Hz frequency. The current will be increased to target a pain rating of 6 of 10 on the NRS (0 = no pain, 10 = worst imaginable pain). Three further adjustments in current will be made every 5 minutes for the next 15 minutes to compensate for habituation. This final current will be kept constant until the end of the particular experiment). In Part 1 duration of OLP analgesia will be examined, and onset and size of the effect will be reevaluated. In Part 2 of this study outcomes between subjects receiving one OLP injection, subjects receiving one repetition of the injection on a fixed time point and subjects receiving one repetition of the injection on-demand will be evaluated
Key facts
- Study ID
- NCT05819476
- Run by
- University Hospital, Basel, Switzerland
- People needed
- 141
- Starts
- 2023-03-23
- Expected to finish
- 2025-06-01
- Last updated by the study team
- 2025-01-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy volunteers (ASA Class I or II), aged 18 to 65 years
- BMI between 18 and 25kg/m2
- Able to understand the study and the NRS
- Able to give informed consent
You may not qualify if…
- Participation in a previous open-label placebo study; for Part 2, this includes Part 1 of this study
- Regular intake of medications or drugs potentially interfering with pain sensation (analgesics, opioids, antihistamines, calcium and potassium channel blockers, serotonin/ noradrenaline reuptake inhibitors, corticosteroids)
- Neuropathy
- Chronic pain
- Neuromuscular disease
- Dermatological disease (i.e. Atopic Dermatitis)
- Psychiatric disease
- Pregnancy / Lactation
Where it is running
- University Hospital of Basel (USB); Department of Anaesthesiology — Basel, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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