End-on Versus Parallel Radiofrequency Lesioning for Neurotomy of the Cervical Medial Branch Nerves

Recruiting now · Not applicable

Conditions studied: Neck Pain, Zygapophyseal Joint Arthritis

In brief

Aim of the EndPaRL study is to compare the efficacy and effectiveness of the two techniques utilizing sharp straight conventional radiofrequency needle with a trident needle for radiofrequency neurotomy of Cervical Medial Branch Nerves (CMBNs), in patients presenting with chronic, moderate-to-severe, neck pain due to cervical zygapophyseal joint osteoarthritis, as diagnosed by positive responses to two consecutive diagnostic blocks with local anesthetic of the CMBN.

Key facts

Study ID

NCT05818774

Run by

University Health Network, Toronto

People needed

72

Starts

2023-03-10

Expected to finish

2028-03-01

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient of either gender aged 18-85 years
• Predominant axial (non-radicular) neck pain for at least 3 months
• 7-day average NRS score for neck pain ≥ 5/10 at baseline evaluation
• Moderate or greater functional impairment due to pain, defined as NDI Questionnaire raw score of 15 out of 50 (≥30% )e Failure to respond to conservative medical management (pharmacologic, physical therapy) for at least 3 months;
• f) Positive response to two consecutive diagnostic blocks of the CMBN with a short and long-acting anesthetic

You may not qualify if…

• Participants with financial incentives or litigation associated with ongoing pain
• Inability to complete assessment instruments
• Chronic widespread pain
• Prior RFN of the CMBN;
• Severe mental health issues
• Pregnancy or other reason that precludes the use of fluoroscopy
• Untreated coagulopathy
• Systemic or local infection at the time of screening.

Where it is running

• Women's College Hospital — Toronto, Ontario, Canada (enrolling)
• University Health Network (UHN) — Toronto, Ontario, Canada (enrolling)
• Division of Pain Medicine, Department of Anesthesiology, Reanimation, and Pain Medicine, Hospital Clínic de Barcelona, University of Barcelona. — Barcelona, Catalonia, Spain

Full record on ClinicalTrials.gov

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