Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock.

Recruiting now · Phase 2

Conditions studied: Cardiac Arrest

In brief

Among patients admitted after an out-of-hospital cardiac arrest (OHCA) in intensive care unit (ICU), almost two thirds of patients will develop in the first hours a post-cardiac arrest (CA) shock. This post-CA shock, combines cardiac and hemodynamic failure, generally resulting in multi-organ failure and early death in up to 35% of patients. Experimental data suggest that intravenous ascorbic acid (vitamin C) may attenuate inflammation and vascular injury related to sepsis or surgery. Preclinical and clinical studies also provide safety data of high dose intravenous vitamin C (\> 200mg/kg/day) with no significant adverse event reported and favorable impact on outcome. Experimental data also suggest beneficial effect of vitamin C in post-CA management with improvement of shock and multi-organ failure with potential benefit on neuroprotection and outcome. The study is a phase II multicenter prospective controlled open-label trial randomized in two parallel groups : * Expérimental group: Standard of care care for post-CA shock + Vitamin C (Vit-C) 200mg/kg/d IV (started as early as possible, no later than 1 h after randomization + thiamin (Vit B1) 200mg every 12 h during 3 days. * Control group: Standard of care care for post CA shock according international guidelines. Patient number to be enrolled : 234, Study duration :24 months and 28 days, Inclusion duration : 24 months, Patient participation : duration : 28 days

Key facts

Study ID

NCT05817851

Run by

Centre Hospitalier de Bethune

People needed

234

Starts

2023-12-27

Expected to finish

2028-01-24

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients still comatose (Glasgow coma scale < 8) after an OHCA of presumed cardiac origin with ROSC < 60 min;
• and treated with a norepinephrin or an epinephrin continuous infusion during at least 30 min before randomization to maintain mean arterial pressure (MAP) ≥ 65 mmHg.

You may not qualify if…

• patients still comatose (Glasgow coma scale < 8) after an OHCA of presumed cardiac origin with ROSC < 60 min;
• and treated with a norepinephrin or an epinephrin continuous infusion ≥ 0.2µg/kg/h, within 4 hours after OHCA, during at least 30 min/h to maintain mean arterial pressure (MAP) ≥ 65 mmHg.
• Exclusion criteria:
• minor or pregnant women;
• OHCA from evident extracardiac cause (trauma, bleeding, poisoning, etc.);
• interval between RACS and randomization > 6 hours;
• extracorporeal circulatory assistance requirement in the first 4 hours after OHCA;
• history of urolithiasis, oxalate nephropathy or hemochromatosis;
• glucose-6-phosphate deshydrogenase deficiency; nephrolithiasis, hyperoxalyurie
• patients already treated with vit-C; known vit-C deficit;
• inclusion in another study;
• pre-existent severe chronic kidney disease (glomerular filtration rate < 30ml/min);
• treatment limitationsor moribound
• Patient with derpived freedom or with legal protective measures.
• Patient not covered by French national health insurance

Where it is running

• Hôpital Lariboisière — Paris, France (enrolling)
• Centre Hospitalier de Rouen — Rouen, France (enrolling)
• Centre Hospitalier Toulon La Seyne sur Mer — Toulon, France (enrolling)
• CH d'Arras — Arras, France (enrolling)
• Centre Hospitalier de Dieppe — Dieppe, France (enrolling)
• GHEF Site Marne La Vallée — Jossigny, France (enrolling)
• Centre Hospitalier de LENS — Lens, France (enrolling)
• Centre Hospitalier Universitaire de LILLE — Lille, France (enrolling)
• Centre Hospitalier Béthune — Béthune, France (enrolling)
• CH de Versailles — Versailles, France
• CHI Nord-Ardennes — Charleville-Mézières, France
• CH de Melun (GHSIF) — Melun, France
• Centre Hospitalier de Valenciennes — Valenciennes, France
• Centre Hospitalier Universitaire d'Amiens — Amiens, France

Full record on ClinicalTrials.gov

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