Urinary Creatinine Excretion Time in the Neonatal Period

Recruiting now · Not applicable

Conditions studied: Renal Function

In brief

Newborn's renal function is difficult to assess and its physiology during the first days of life is still incompletely known. Studies suggest that the newborn almost completely reabsorbs creatinine during the first 48 to 72 hours of life, while at the same time it continues to produce its own creatinine. Therefore, the initial stock of creatinine at birth still increases through this production and the non or weak clearance. A better knowledge of renal physiopathology in newborns would allow to improve the therapeutic management of the infants, particularly in case of potential nephrotoxicity. No study has attempted to assess the increase in urinary creatinine excretion in neonates from a given time. Objectives: To show when urinary creatinine excretion in newborns is efficient. Results: this study mightr show an inflection point in urinary creatinine excretion illustrating the postnatal age when renal function becomes efficient.

Key facts

Study ID

NCT05813730

Run by

Central Hospital, Nancy, France

People needed

40

Starts

2024-10-30

Expected to finish

2025-12-01

Last updated by the study team

2025-02-19

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All full-term newborns (37WA or more)
• From a physiological and spontaneous pregnancy
• Good neonatal adaptation (Apgar 7 at 5 minutes of life)
• Eutrophic (weight > 10th percentile and < 90th percentile)

You may not qualify if…

• Newborns for whom no urine sample is interpretable
• Those with a significant clinical-biological anomaly
• Neonates with hemodynamic disorders such as low blood pressure (median < gestational age) or hypovolemia (shock, signs of dehydration, need for volume expansion) during the first 3 days of life

Where it is running

• Maternite Regionale Universitaire CHRU NANCY — Nancy, Lorraine, France (enrolling)

Full record on ClinicalTrials.gov

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