Impact of Glycine Therapy on Peri-implant Mucositis

Completed · Not applicable

Conditions studied: Peri-implant Mucositis

In brief

The purpose of this research study is to determine the impact of glycine powder air-abrasive debridement (GPAD) on the microbiology of the tissues surrounding dental implants with health and inflammation (peri-implant mucositis).

Key facts

Study ID

NCT05810558

Run by

Ohio State University

People needed

30

Starts

2016-06-16

Expected to finish

2020-12-30

Last updated by the study team

2023-04-12

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years
• Must have >1 tooth-borne, non-splinted single dental implant
• Signs of healthy dental implants (pocket probing depth <4mm and a lack of bleeding upon probing at peri-implant site) OR
• Signs of peri-implant mucositis (> 4mm probing pocket depths at the dental implant site, bleeding upon probing at >1 peri-implant site, pre-brushing plaque score of > 1.9 (modified Plaque Index (mPI)), and radiographic evidence of bone loss less than 2mm).

You may not qualify if…

• Uncontrolled medical condition (i.e. Diabetes, History of smoking <5 years)
• Pregnant or lactating females
• Untreated periodontal conditions
• Use of antibiotics in the past 3 months
• Subjects treated with medication for >2 weeks with known effects to the oral tissues (i.e. coumadin, phenytoin, nifedipine, cyclosporine, non-steroidal anti-inflammatory drugs)
• Signs of peri-implantitis (pocket probing depth of 4-6mm with bleeding upon probing at >1 peri-implant site AND radiographic bone loss)
• Dental implant mobility

Where it is running

• College of Dentistry — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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