Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.

Recruiting now · Phase 1

Conditions studied: Advanced Adenocarcinoma

In brief

The objective of this study is to assess safety and efficacy of BA3182 in Advanced Adenocarcinoma

Key facts

Study ID

NCT05808634

Run by

BioAtla, Inc.

People needed

168

Starts

2023-07-14

Expected to finish

2028-09-15

Last updated by the study team

2025-09-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically confirmed locally advanced unresectable or metastatic adenocarcinoma
• Age ≥ 18 years
• Adequate renal function
• Adequate liver function
• Adequate hematological function
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

You may not qualify if…

• Patients must not have clinically significant cardiac disease.
• Patients must not have known non-controlled CNS metastasis.
• Patients must not have active autoimmune disease or a documented history of autoimmune disease.
• Patients must not have a history of ≥ Grade 3 allergic reactions to mAb therapy as wellas known or suspected allergy or intolerance to any agent given during this study.
• Patients must not incomplete recovery from the effects of major surgery or significant traumatic injury before the first dose of study treatment.
• Patients must not have known human immunodeficiency virus (HIV) infection, active hepatitis B and/or hepatitis C.
• Patients must not be women who are pregnant or breast feeding.

Where it is running

• UC Irvine — Irvine, California, United States (enrolling)
• USC Norris Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
• Yale Cancer Center — New Haven, Connecticut, United States (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• University of Illinois — Chicago, Illinois, United States (enrolling)
• Karmanos Cancer Institute — Detroit, Michigan, United States (enrolling)
• The Christ Hospital Cancer Center — Cincinnati, Ohio, United States (enrolling)
• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States (enrolling)
• Fred Hutch Cancer Center — Seattle, Washington, United States (enrolling)

Full record on ClinicalTrials.gov

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