A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Bladder Spasms

In brief

This research is being done to find out whether intravenous magnesium is effective in the treatment of bladder spasms after urologic surgery.

Key facts

Study ID

NCT05806996

Run by

Mayo Clinic

People needed

120

Starts

2023-07-31

Expected to finish

2026-12-31

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Be undergoing a bladder invasive procedure with or without planned urinary catheter on Mayo Clinic Gonda 7 Outpatient Procedure Center.

You may not qualify if…

• Are unable to grant informed consent or comply with study procedure.
• Allergy or known sensitivity to magnesium or Renacidin.
• Expected or high risk of bladder extravasation.
• Ongoing atrial fibrillation prior to surgery.
• Are undergoing emergency surgery.
• Are pregnant.
• Known hypermagnesemia.
• Patients with neuromuscular weakness (e.g., Myasthenia gravis) due to magnesium's muscle weakening effect.
• Patients with myocardial compromise or cardiac conduction defects because of magnesium's anti-inotropic effects.
• Patients with renal insufficiency, glomerular filtration rate less than 30, since Magnesium is eliminated by the kidneys resulting in exaggerated rise in serum magnesium.
• Patients with concomitant use of a calcium channel blocker since magnesium sulfate could act synergistically to suppress muscular contractility.

Where it is running

• Mayo Clinic in Minnesota — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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