Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery
Recruiting now
Conditions studied: Post-Dural Puncture Headache
In brief
The aim of this study is to examine the effects of altitude (high altitude versus low altitude) on incidence and severity of postural puncture headache (PDPH) following spinal anaesthesia for caesarean delivery. The investigators hypothesized that the risk of PDPH would be higher in highlander parturients than in lowlander parturients.
Key facts
- Study ID
- NCT05804448
- Run by
- B.P. Koirala Institute of Health Sciences
- People needed
- 292
- Starts
- 2023-04-18
- Expected to finish
- 2026-04-20
- Last updated by the study team
- 2025-09-19
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Parturient, aged more than or equal to 18 years
- American society of Anesthesiologist 2 and 3
- Scheduled for elective and non-elective (category 2 \& 3) caesarean delivery with spinal anesthesia
- Native to their resident altitude i.e., those born, raised, and have continuously lived at the same altitude, at least for the past 1 year.
You may not qualify if…
- Hypertensive disorder
- Cerebrovascular disease
- Mental disorder (schizophrenia and other psychotic disorders)
- Known fetal anomalies
- Contraindication to spinal anaesthesia.
- Those requiring general anaesthesia for delivery due to failed spinal anesthesia
- Major post-delivery complications (severe haemorrhage, sepsis, or ICU admission)
- Those who migrate from their resident altitude (either low to high or vice versa) within 7 days post-delivery will also be excluded.
Where it is running
- Karnali Academy of Health Sciences — Jumla, Karnali, Nepal (enrolling)
- BP Koirala Institute of Health Sciences (BPKIHS) — Dharān, Koshi, Nepal (enrolling)
Full record on ClinicalTrials.gov
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