A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer
Running, not enrolling · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Non-small Cell Lung Cancer
In brief
This study is researching an investigational drug called fianlimab (also called REGN3767) with two other medications called cemiplimab and chemotherapy, individually called a "study drug" or collectively called "study drugs". 'Investigational' means that the study drug is not approved for use outside of this study by any Health Authority. Examples of chemotherapy drugs include the following: Paclitaxel plus carboplatin, and Pemetrexed plus cisplatin. The study is being conducted in patients who have advanced non-small cell lung cancer (NSCLC). The aim of the study is to see how effective the combination of fianlimab, cemiplimab, and chemotherapy is for treating advanced NSCLC, in comparison with cemiplimab and chemotherapy. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs * How much of each study drug is in your blood at different times * Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects) * How administering the study drugs might improve your quality of life
Key facts
- Study ID
- NCT05800015
- Run by
- Regeneron Pharmaceuticals
- People needed
- 160
- Starts
- 2023-08-08
- Expected to finish
- 2031-12-23
- Last updated by the study team
- 2026-07-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yuma Regional Medical Center — Yuma, Arizona, United States
- The Oncology Institute of Hope & Innovation — Cerritos, California, United States
- Crosson Cancer Institute — Fullerton, California, United States
- St. Joseph Hospital Orange — Orange, California, United States
- Desert Hematology Oncology Medical Group Incorporated — Rancho Mirage, California, United States
- Emad Ibrahim, MD, Inc. — Redlands, California, United States
- PIH Health Hospital — Whittier, California, United States
- Rocky Mountain Regional VA Medical Center — Aurora, Colorado, United States
- Yale Cancer Center — New Haven, Connecticut, United States
- Clermont Oncology Center — Clermont, Florida, United States
- Miami Veterans Administration HealthCare System — Miami, Florida, United States
- Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
- Tallahassee Memorial Healthcare — Tallahassee, Florida, United States
- University of Illinois — Chicago, Illinois, United States
- Northwest Oncology and Hematology — Rolling Meadows, Illinois, United States
- Mary Bird Perkins Cancer Center — Baton Rouge, Louisiana, United States
- Hattiesburg Clinic — Hattiesburg, Mississippi, United States
- Capital Health Hopewell Medical Center — Pennington, New Jersey, United States
- New Mexico Cancer Care Alliance — Albuquerque, New Mexico, United States
- NYU Langone Health Perlmutter Cancer Center — New York, New York, United States
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
- Montefiore Medical Center — The Bronx, New York, United States
- Clinical Research Alliance Inc — Westbury, New York, United States
- Gabrail Cancer Center Research — Canton, Ohio, United States
- Arizona Clinical Research Center — Tucson, Arizona, United States
Full record on ClinicalTrials.gov
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