Study of the Role of Genetic Modifiers in Hemoglobinopathies
Recruiting now
Conditions studied: Sickle Cell Disease, Thalassemia, Beta, Thalassemia Alpha, Hemoglobinopathies
In brief
This study will investigate the role of genetic modifiers in hemoglobinopathies through a large-scale, multi-ethnic genome-wide association study (GWAS).
Key facts
- Study ID
- NCT05799118
- Run by
- Cyprus Institute of Neurology and Genetics
- People needed
- 30000
- Starts
- 2022-10-01
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2024-03-20
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinical diagnosis of an inherited hemoglobinopathy, including sickle cell disease (SCD), β-thalassemia, and α-thalassemia; all genotypes will be considered.
- Age ≥ 2 years old at the time of the collection of the phenotypic data.
- There will be no limits on study participants in terms of gender, ethnicity, morbidities.
You may not qualify if…
- Patients treated with stem cell transplantation or genetic therapy.
- Age < 2 years old at the time of the collection of the phenotypic data.
- Patient or legal representative for minors unwilling or unable to give consent.
Where it is running
- Ampang Hospital — Ampang, Malaysia (enrolling)
- Universiti Kebangsaan Malaysia — Bangi, Malaysia (enrolling)
- Universiti Sains Malaysia — Kota Bharu, Malaysia (enrolling)
- University of Abuja — Abuja, Nigeria (enrolling)
- Kaduna State University — Kaduna, Nigeria (enrolling)
- Ahmadu Bello University — Zaria, Nigeria (enrolling)
- Archbishop Makarios III Hospital — Nicosia, Cyprus (enrolling)
- Paphos General Hospital — Paphos, Cyprus (enrolling)
- Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
- Centre Hospitalier Monkole — Kinshasa, Democratic Republic of the Congo (enrolling)
- Rigshospitalet — Copenhagen, Denmark (enrolling)
- Hippokrateio Hospital of Athens — Athens, Greece (enrolling)
- Laiko General Hospital — Athens, Greece (enrolling)
- Lucrecia Paím Maternity — Luanda, Angola (enrolling)
- General Hospital of Larissa — Larissa, Greece (enrolling)
- Larnaca General Hospital — Larnaca, Cyprus (enrolling)
- Limassol General Hospital — Limassol, Cyprus (enrolling)
- Hospital Clínico San Carlos — Madrid, Spain
- University of Buenos Aires — Buenos Aires, Argentina
- University Hospitals Leuven — Leuven, Belgium
- Universiti Brunei Darussalam — Brunei, Brunei
- National and Kapodistrian University of Athens — Athens, Greece
- Emek Medical Centre — Afula, Israel
- University of Turin — Turin, Italy
- University of Lahore — Lahore, Pakistan
Full record on ClinicalTrials.gov
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