Neoadjuvant Anti-PD-1 Immunotherapy With Chemotherapy in Resectable Locally Advanced Oral Squamous Cell Carcinoma

Recruiting now · Phase 3

Conditions studied: Oral Squamous Cell Carcinoma

In brief

The purpose of this study is to investigate the survival benefit of neoadjuvant anti-PD-1 immunotherapy plus TP chemotherapy compared with TP chemotherapy or up-front surgery in resectable locally advanced oral squamous cell carcinoma.

Key facts

Study ID

NCT05798793

Run by

Hospital of Stomatology, Wuhan University

People needed

309

Starts

2023-11-21

Expected to finish

2026-10-01

Last updated by the study team

2024-04-02

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically documented oral squamous cell carcinoma (biopsy required).
• Local advanced oral squamous cell carcinoma (clinical stage T1-2N1-2M0, T3-4aN0-2M0) with resection option for potential cure, as assessed by a faculty surgeon at Hospital of Stomatology, Wuhan University.
• Distant metastasis is excluded by chest CT and emission computed tomograph.
• Adequate organ function as follows: 1) Leukocyte count ≥ 2,000/mm3; 2) Absolute neutrophil count ≥ 1,000/mm3; 3) Platelet count ≥ 100,000/mm3; 4) Hemoglobin ≥ 90 g/L; 5) Serum albumin ≥30 g/L; 6) Total bilirubin ≤ 1.5 × upper limit of normal (ULN); 7) AST (SGOT) and ALT (SGPT) < 2.5 × ULN; 8) ALP ≤ 2.5 × ULN; 9) Prothrombin time-international normalized ratio ≤ 1.5; 10) Serum creatinine ≤ 1.5 × ULN; 11) INR/PT≤ 1.5; 12) TSH ≤ ULN.
• ECOG performance status 0-1.
• Female patient tested HCG negative in serum or urine within 7 days prior to the start of investigational product. Both patient and partner must agree to use contraception prior to study entry and for the duration of study participation and for up to 120 days after the last dose of PD-1 blockade.
• Patient understands the study regimen, its requirements, risks and discomforts and is able and willing to sign the informed consent form.

You may not qualify if…

• History of ≥ 3 grade immune related adverse events (irAEs) or have not recovered to ≤ 1 grade irAEs from previous treatment.
• History of other treatments for cancer, including surgery, chemotherapy, radiotherapy or molecular targeted therapy within past 5 years.
• Previous therapy with anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 or any other antibody targeting T cell co-regulatory pathways.
• Active autoimmune disease or history of refractory autoimmune disease.
• Active systemic infection requiring therapy.
• Patients who are receiving psychotropic drug or alcohol/drug abuse.
• Subjects with concurrent other active malignancies.
• HIV or untreated active HBV or HCV infections, or vaccinated (HBV, flu, varicella, etc) within 4 weeks before recruitment.
• Uncontrollable systemic diseases, including diabetes, hypertension, etc.
• History of stroke or transient ischemic attack within past 6 months.
• Distant metastases or inability to resect after physician evaluation.
• Serious cardiovascular, respiratory, immune system critical disease or other conditions that the researchers thought might increase the subjects' risk.

Where it is running

• Hospital of Stomatology, Wuhan University — Wuhan, Hubei, China (enrolling)
• Xiangya Hospital of Central South University — Changsha, Hunan, China (enrolling)
• Peking university Shenzhen hospital — Shenzhen, Guangdong, China

Full record on ClinicalTrials.gov

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