Household Transmission Dynamics of Multidrug Resistant Enterobacterales
Recruiting now
Conditions studied: Adults Patients, With Fecal Carriage of Multi-Drug Resistant Enterobacterales (MDR-E)
In brief
The HOME study will prospectively follow a cohort of Multi-Drug Resistant Enterobacterales (MDR-E) carriers after hospital discharge, and their related household members over a 3-month period. The main objective is to estimate the rate of confirmed transmissions of MDR-E from the index cases to related household members, and identify predictors associated with transmission. Transmission will be confirmed by comparing genomic analysis of the MDR-E strains isolated both in the index patient and his/her household members, based on the number of Single nucleotide polymorphisms (SNPs) differences between nearby genomes by Variant Calling. Multifactorial processes involved in MDR-E transmission in households will be explored with stochastic individual-based modelling. The parameterized model will be used to simulate and assess different strategies of control of MDR-E emergence and transmission to households. The impact of modifying patterns of human-contacts, promote hygiene and control barriers (decontamination of objects or surfaces, variations in antibiotic use, reinforcement of hand hygiene) will be assessed.
Key facts
- Study ID
- NCT05798364
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 507
- Starts
- 2023-05-19
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2024-06-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Index patients
- adults (≥ 18 years)
- hospitalized in participating hospitals
- positive for MDR-E fecal carriage on routine screening during hospital stay
- with no documented MDR-E fecal carriage in the 12 months preceding current hospitalization
- regularly living with at least two additional household members who expressed their non-opposition to participate.
- planning to live in Ile de France for the next three months Household members
- adults or children living in the same household as the index case (i.e. sharing the same kitchen and/or bathroom and/or toilets) during the 3 months following inclusion, and who expressed their non-opposition to participate.
- planning to live in Ile de France for the next three months
You may not qualify if…
- Lack of non-opposition to participate and to use clinical data
- Subject under legal protection (guardianship)
- Subject deprived of liberty under judicial constraint
- Subject undergoing psychiatric care
- Lack of affiliation to a social security scheme Secondary exclusion criteria
- Index member negative for MDR-E fecal carriage either before discharge (D-7 to D-2) or on day of discharge (D0)."
Where it is running
- Bichat Hospital — Paris, Île-de-France Region, France (enrolling)
Full record on ClinicalTrials.gov
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