Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment

Recruiting now · Not applicable

Conditions studied: Primary Hyperaldosteronism Due to Adrenal Adenoma

In brief

This is a prospective randomized controlled trial where quality of life and the effectiveness of treatment will be evaluated in 80 patients with confirmed unilateral primary aldosteronism ,randomly assigned to be either treated surgically with unilateral adrenalectomy or to receive medical treatment with eplerenone.

Key facts

Study ID

NCT05797558

Run by

Göteborg University

People needed

80

Starts

2023-04-28

Expected to finish

2028-05-28

Last updated by the study team

2025-04-06

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with confirmed unilateral PA
• Age 18-70 years
• Candidate for surgical treatment
• No contraindications for minimally invasive surgery or treatment with MRA
• Understands oral and written information and provides oral and written informed consent.

You may not qualify if…

• Unwilling or unable to undergo surgery
• Unwilling to accept medical treatment for 12 months and not receiving standard treatment (surgery)
• Impaired renal function with eGFR <45 ml/min/1,73m2
• P-cortisol >138 nmol/L following 1-mg overnight dexamethasone suppression test.

Where it is running

• University of Gothenburg — Gothenburg, Sweden (enrolling)
• Karolinska University Hospital, Stockholm, Sweden. — Stockholm, Sweden
• Umeå University, Umeå, Sweden. — Umeå, Sweden

Full record on ClinicalTrials.gov

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