Measuring Oncological Value of Exercise and Statin
Recruiting now · Phase 3
Conditions studied: Prostate Cancer, Breast Cancer, Kidney Cancer, Ovarian Cancer, Metastatic Breast Cancer, Metastatic Kidney Cancer, Metastatic Renal Cell Carcinoma, Metastatic Renal Cancer, Metastatic Prostate Cancer, Metastatic Prostate Adenocarcinoma, Metastatic Ovarian Cancer, Metastatic Ovary Cancer
In brief
The aim of the study is to find out whether supervised physical exercise during cancer drug treatment improves the effectiveness of the treatment in metastasized breast, kidney, ovarian and prostate cancer compared to unsupervised exercise. In addition, the investigators are investigating whether the use of atorvastatin combined with guided group exercise training would further improve the response to cancer treatment.
Key facts
- Study ID
- NCT05796973
- Run by
- Tampere University Hospital
- People needed
- 240
- Starts
- 2023-03-31
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2025-06-27
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- The patient has metastatic prostate cancer, breast cancer, ovarian cancer or kidney cancer confirmed histologically and by imaging, for which 1st-line cancer drug treatment is started
- Prostate cancer: First course of docetaxel treatment or second-generation antiandrogen treatment for metastatic prostate cancer.
- Breast cancer: First-line medical treatment of metastatic breast cancer regardless of hormone receptor status.
- Kidney cancer: Kidney cancer, for which 1st-line cancer drug treatment is started as tki monotherapy and/or IO monotherapy or as a combination therapy.
- Ovarian cancer: stage III or IV cancer for which chemotherapy treatment is started.
- The patient agrees to the study and signs a written informed consent.
- Adult (18 years=>) women (breast, ovarian and kidney cancer) and men (prostate and kidney cancer) are recruited for the study.
- In women, the use of a reliable contraceptive during the intervention
You may not qualify if…
- High risk of bone fractures
- Inability to physical exertion and/or unsuitability for cancer drug treatment
- Poor co-operation ability for psychological reasons
- Active use of cholesterol-lowering drugs
- Severe liver or kidney failure
- Troublesome side effects that occurred in the past during cholesterol medication
- Continuous use of medicinal substances that interact with atorvastatin during the study period
- A special group of subjects according to the EU Clinical Trials Regulation 536/2014 (e.g. pregnant or lactating women)
- Exclusion criteria in patients who are already using statin medication before the study:
- High risk of bone fractures
- Inability to physical exertion and/or unsuitability for cancer drug treatment
- Poor co-operation ability for psychological reasons
- Severe liver or kidney failure
- A special group of subjects according to the EU Clinical Trials Regulation 536/2014 (e.g. pregnant or lactating women)
Where it is running
- Tampere University Hospital — Tampere, Länsi-Suomi, Finland (enrolling)
Full record on ClinicalTrials.gov
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