Environmental Mixtures, Cognitive Control and Reward Processes, and Risk for Psychiatric Problems in Adolescence

Running, not enrolling

Conditions studied: Psychiatric Problem

In brief

This study aims to examine the cognitive and neural pathways underlying the joint impact of chemical and social exposures on two aspects of cognitive function: cognitive control and reward processing. The investigators will use high resolution, multi-band resting state and task functional magnetic resonance imaging (fMRI) as well as neuromelanin stain MRI to identify pathways through which exposure to a mixture of prenatal chemical and early life social exposures alters brain function and behavior. Specifically, the investigators will leverage extant prenatal exposure data (N=550) from the Columbia Center for Children's Environmental Health (CCCEH) Mothers and Newborns (MN) birth cohort and study symptoms and brain function in adolescence.

Key facts

Study ID

NCT05795452

Run by

Ohio State University

People needed

250

Starts

2022-02-20

Expected to finish

2026-05-01

Last updated by the study team

2026-02-25

Who can join

Age: 13 and older, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adolescents between 13-20 years
• Available prenatal exposure data
• Adolescents and parents are English- or Spanish-speaking

You may not qualify if…

• Presence of metallic device or dental braces
• Full Scale Intelligence Quotient (IQ) < 70 at prior assessment
• Pregnant women or lactating women

Where it is running

• Columbia University Irving Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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