The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Recruiting now · Not applicable

Conditions studied: Air Pollution

In brief

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Key facts

Study ID

NCT05794087

Run by

Rutgers, The State University of New Jersey

People needed

120

Starts

2023-02-07

Expected to finish

2027-06-01

Last updated by the study team

2025-12-17

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Cardiovascular disease
• Respiratory disease
• Recent (within 4 weeks) respiratory or COVID-19 symptoms
• Diabetes
• Pregnancy
• HIV Infection
• History of smoking within the past 5 years.
• Orthopedic or rheumatologic conditions which would interfere with cycle use
• Inability to produce a sputum plug at screening
• Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.

Where it is running

• Rutgers - EOHSI — Piscataway, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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