Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block
Recruiting now · Phase 4
Conditions studied: Analgesia
In brief
Background: Many thyroidectomy patients suffer from postoperative pain that could delay early hospital discharge and place a significant burden on both the patient and the healthcare team. Bilateral intermediate cervical plexus block (ICPB) provides good analgesia for neck surgery, including thyroidectomy. However, the duration of a single-shot nerve block is usually short. Therefore, adjuvants are used in peripheral nerve blocks. Objectives: To compare the safety and efficacy of dexmedetomidine versus dexamethasone as adjuvants to bupivacaine in ultrasound-guided intermediate cervical plexus block in patients undergoing total thyroidectomy under general anesthesia. Patients and Methods: This is a randomized, double-blind, phase four, prospective clinical trial; carried out on 60 patients, who were candidates for total thyroidectomy under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received bilateral ICPB with isobaric bupivacaine plus dexmedetomidine, and group B, received bilateral ICPB with isobaric bupivacaine plus dexamethasone.
Key facts
- Study ID
- NCT05793060
- Run by
- Damanhour Teaching Hospital
- People needed
- 60
- Starts
- 2025-08-01
- Expected to finish
- 2026-12-15
- Last updated by the study team
- 2026-01-12
Who can join
Age: 21 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- American Society of Anesthesiologists (ASA) physical status ≤ II
- Age from 21 to 60 years
- Body Mass Index (BMI) ≤ 35 kg/m2
You may not qualify if…
- ASA physical status > II
- Age < 21 years or > 50 years
- BMI > 35 kg/m2
- Bronchial asthma
- Chronic obstructive pulmonary disease
- Restrictive lung diseases
- Sick sinus syndrome
- Sinus bradycardia
- Hypertension
- Chronic hypotension
- Ischemic heart disease
- Coagulopathies
- Hepatic insufficiency
- Renal insufficiency
- Diabetes mellitus
- Peripheral neuropathy
- Thyroid malignancy
- Hyperthyroidism
- Substernal goiter
- Patients on beta-blockers
- Patients using pacemakers
- Alcohol or drug abuse
- Allergy to the study drugs
Where it is running
- Damanhour Teaching Hospital — Damanhūr, El-Beheira, Egypt (enrolling)
Full record on ClinicalTrials.gov
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