Postprandial Monocyte Study

Completed · Not applicable

Conditions studied: Immune System, Nutrition, Inflammation

In brief

The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal. Previous studies have found that monocytes are important for blood vessel health. In this study, two different high-fat meals will be used to study the effect of different types of dietary fat on postprandial NCMs. The investigators will characterize NCMs in both fasting conditions and following consumption of two different high-fat meals, and will evaluate whether the type of fat in a meal affects NCMs in blood.

Key facts

Study ID

NCT05792137

Run by

USDA, Western Human Nutrition Research Center

People needed

32

Starts

2023-11-14

Expected to finish

2024-10-11

Last updated by the study team

2025-03-12

Who can join

Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• BMI 18.5 - 29.9 kg/m²
• have a bank account and social security number or taxpayer identification for financial compensation

You may not qualify if…

• Pregnant or lactating women
• Known allergy or hindering intolerance to study meal ingredients
• Systolic blood pressure greater than 140 mmHg or diastolic blood pressure greater than 90 mmHg measured
• Fasting glucose above 105 mg/dL
• Triglycerides above 150 mg/dL
• HDL cholesterol less than 40 mg/dL (men) and 50 mg/dL (women)
• Self-reported history of difficulties with blood drawing procedures including prior fainting or dizziness, or veins assessed as not suitable for four separate venipunctures by licensed phlebotomist
• Diagnosed active chronic diseases for which the individual is currently taking daily medication, including but not limited to Diabetes mellitus, Cardiovascular disease, Cancer, Gastrointestinal disorders, Kidney disease, Liver disease, Bleeding disorders, Asthma, Autoimmune disorders, Hypertension, Osteoporosis
• Recent minor surgery (within 4 wk) or major surgery (within 16 wk)
• History of gastrointestinal surgery, including gastric bypass surgery or resection
• Recent antibiotic therapy (within 4 wk)
• Known gallbladder disease or history of cholecystectomy
• Recent hospitalization (within 4 wk)
• Use of prescription medications at the time of the study that directly affect endpoints of interest (e.g. hyperlipidemia, glycemic control, steroids, statins, anti-inflammatory agents, and over-the-counter weight loss aids)
• Current participation in another research study
• Less than 18 and over 39 years old
• BMI less than 18.5 and above 29.9 kg/m²
• Has HIV/AIDS or another disease that affects the immune system
• Unable to fast for 12 hours
• Gives regular blood donations and is unwilling to stop during the study
• Has monocytosis (>0.8 x 10³/microliter) or other abnormalities in hematologic parameters based on a screening complete blood count (CBC) with differential

Where it is running

• USDA Western Human Nutrition Research Center — Davis, California, United States

Full record on ClinicalTrials.gov

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