Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound

Starting soon · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

Through the BrainBox Initiative, investigators propose to study the effects of motor tFUS on Motor Evoked Potentials (MEPs) and GABA and Glutamate Concentrations in the Brain.

Key facts

Study ID

NCT05792020

Run by

Medical University of South Carolina

People needed

25

Starts

2026-07-01

Expected to finish

2028-12-31

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female
• Age 18-55
• Endorse good health with no history of mental or physical illness or implanted metal
• English as a primary language
• Capacity to consent
• Negative urine pregnancy test if a female of childbearing potential
• Willingness to adhere to the tFUS and MRI study schedule

You may not qualify if…

• Any psychotropic medication is taken within 5 half-lives of procedure time
• Any head trauma resulting in loss of consciousness
• Personal or family history of neurological illness or injury
• Alcohol or substance abuse or dependence (other than tobacco) in the past week
• Diagnosis or current treatment (pharmacological or otherwise) of any psychiatric condition
• Pregnancy
• Personal or family history of seizures or epilepsy
• Claustrophobia or inability to stay still in the MR scanner environment
• Any metal in the body
• Other contraindications to electrical or electromagnetic stimulation
• Hair in dreadlocks, braids, or weave
• Diagnosis of COVID-19 in the past 14 days
• Inability to adhere to the treatment schedule.

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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