Interest of Follicular Helper Lymphocytes / Regulatory Follicular Helper Lymphocytes Ratio in IgA Nephropathy

Recruiting now · Not applicable

Conditions studied: Glomerulonephritis, IGA

In brief

This study aims to investigate the relevance of the Tfh/Tfr (Follicular helper T cells/ Follicular regulatory T cells) ratio in patients with IgA nephropathy: * To identify a differential expression of the Tfh/Tfr ratio in patients considered stable or progressive * To predict, at diagnosis, the clinical evolution of the disease (progressive or stable form) in the first year.

Key facts

Study ID

NCT05791162

Run by

Centre Hospitalier Universitaire de Besancon

People needed

75

Starts

2023-05-23

Expected to finish

2026-05-01

Last updated by the study team

2024-11-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• IgA nephropathy histologically proven on renal biopsy according to KDIGO criteria, with 8 permeable glomeruli (patients diagnosed from 2009 with a minimum follow-up for their nephropathy of 5 years (arm 1) or patients diagnosed during the study (arm 2))
• Control patients: Lupus or ANCA-associated vasculitis or polycystic kidney disease (arm 3)

You may not qualify if…

• Legal incapacity or limited legal capacity
• Subjects with no social security coverage.
• Pregnancy / No effective contraceptive method

Where it is running

• Centre Hospitalier Universitaire de Besançon — Besançon, France (enrolling)

Full record on ClinicalTrials.gov

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