Almonds to Improve Gut Health and Decrease Inflammation

Running, not enrolling · Not applicable

Conditions studied: Metabolic Syndrome, Dysbiosis, Inflammation

In brief

Almonds are a good source of beneficial compounds. This study will investigate if eating almonds everyday for 12 weeks can affect gut health and inflammation in persons with metabolic syndrome. Investigators will measure changes in metabolism, heart health, and the levels of vitamins and other compounds from almonds.

Key facts

Study ID

NCT05790564

Run by

Oregon State University

People needed

80

Starts

2022-11-17

Expected to finish

2027-07-01

Last updated by the study team

2026-05-05

Who can join

Age: 35 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 35-60 years
• 3 or more of the following: hypertension (systolic BP 130-179 mmHg or diastolic BP 85-119 mmHg); hyperglycemia (fasting glucose 100-599 mg/dL); central obesity [waist circumference greater than 40.1 inches (M) or 34.6 inches (F); hypertriglyceridemia (150-499 mg/dL); low HDL [lower than 40 mg/dL (M) or 50 mg/dL (F)]
• Willing to restrict consumption of nuts other than study nuts for 1 week prior to and throughout the study (13 weeks)
• Willing to stop probiotic supplements one week prior to and during the study (13 weeks)
• Willing to stop multivitamins and supplements containing vitamin E, magnesium, calcium, iron, zinc and copper one week prior to and during the study (13 weeks)
• Willing to complete intake diaries during the study
• Willing to maintain current eating patterns (no significant diet change during study)

You may not qualify if…

• Weekly consumption of almonds, hazelnuts, peanuts and sunflower seeds combined greater than 2 servings (about 2 oz) in the past 3 months
• Nut, wheat, or gluten allergy/intolerance
• Regular use of vitamin E supplements
• Consume more than 2 alcoholic drinks daily
• Tobacco use, including e-cigarettes, or smoking of any substance (e.g. cannabis) in the past 3 months
• Pregnancy, breastfeeding, or planning to become pregnant before completing the study
• Vigorous exercise greater than 7 hours/week
• History of cardiovascular disease, liver disease or cancer
• Have had bariatric surgery (e.g. gastric bypass, gastric banding, sleeve gastrectomy, etc.), other gastrointestinal procedures (e.g. cholecystectomy), disorders (e.g. Crohn's disease, celiac disease, ulcerative colitis) or chronic diarrhea
• Diagnosis of hemochromatosis
• Chronic use (daily intake in past 30 days) of anti-inflammatory medication (steroid or NSAID)
• Use of ezetimibe or orlistat
• Use of oral antibiotic medication within the past month
• Body Mass Index (BMI) <25.0 or >35.0 kg/m2
• Regular use of multivitamin supplements in the past 3 months
• Physician prescribed use of probiotic, vitamin E, magnesium, calcium, iron, zinc or copper supplements

Where it is running

• Oregon State University — Corvallis, Oregon, United States

Full record on ClinicalTrials.gov

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