Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle

Completed · Not applicable · Has a placebo group

Conditions studied: Blood Flow Restriction Training, Betaine Supplementation

In brief

The purpose of the study is to determine whether there is a synergistic effect via combining both low-load blood flow restriction (BFR) training and betaine supplementation loading (6g/day for 14 days) on skeletal muscle anabolic signaling pathways that is mediated by enhancements in intracellular water. These effects are proposed to be greater than either BFR training or betaine supplementation alone or compared to control conditions (high-load non-occluded and/or placebo supplementation).

Key facts

Study ID

NCT05790070

Run by

Baylor University

People needed

20

Starts

2021-02-01

Expected to finish

2021-07-30

Last updated by the study team

2023-03-29

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Only participants considered low risk for cardiovascular disease with no contraindications to exercise as outlined by the ACSM
• Have not consumed any nutritional supplements (aside from a multi-vitamin) one month prior to investigation
• Blood pressure <140/90mmHg
• Resting heart rate <90bpm-

You may not qualify if…

• sedentary individual as defined by the ACSM guidelines.
• inadequate resistance training experience (<12 months, <3x/week)
• vegetarian, vegan, or have dietary restrictions or supplements that potentially affect betaine metabolism.
• allergy to topical anesthetics.
• known metabolic or cardiovascular disorder including heart disease, arrhythmias, diabetes, thyroid disease, or hypogonadism.
• genetic disorders/polymorphisms that would act as direct contraindications to betaine supplementation (i.e. methyltetrahydrofolate reductase, hyperhomocysteinemia, etc.)
• bleeding disorder, history of pulmonary disease, hypertension, hepatorenal disease, musculoskeletal disorders, neuromuscular/ neurological diseases, autoimmune disease, cancer, peptic ulcers, anemia, or chronic infection (e.g., HIV).
• resting systolic/diastolic blood pressure and heart rate of more than 140/90 mmHg and 90, respectively.
• taking any blood thinning (e.g., warfarin, Jantoven, etc.), heart, pulmonary, thyroid, anti-hyperlipidemic, hypoglycemic, anti-hypertensive, endocrinologic (e.g, thyroid, insulin, etc), emotional/psychotropic (e.g., Prednisone, Ritalin, Adderall), or neuromuscular/neurological medications.
• taking anabolic androgenic steroids within the past year.

Where it is running

• Baylor University — Waco, Texas, United States

Full record on ClinicalTrials.gov

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