A Study of BPI-460372 in Advanced Solid Tumor Patients

Recruiting now · Phase 1

Conditions studied: Advanced Solid Tumor

In brief

This study is an open-label, single arm, dose escalation and dose expansion phase 1 study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of BPI-460372 in solid tumor patients.

Key facts

Study ID

NCT05789602

Run by

Betta Pharmaceuticals Co., Ltd.

People needed

82

Starts

2023-04-24

Expected to finish

2026-04-17

Last updated by the study team

2025-01-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed informed consent;
• Age ≥18, male and female patients；
• Expected survival ≥ 3 months；
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1;
• Dose escalation phase: histologically or cytologically confirmed locally advanced or metastatic solid tumor patients, who had disease progression after standard therapy, intolerable to standard therapy, refuse to standard therapy or for whom no standard therapy exists;
• Dose expansion phase: histologically or cytologically confirmed locally advanced Malignant mesothelioma, Epithelioid hemangioendothelioma or other diagnosed solid tumor patients with NF2 defects, YAP/TAZ fusion, LATS1/2 mutations, and other Hippo signaling pathway abnormalities , who had disease progression after standard therapy, intolerable to standard therapy, refuse to standard therapy or for whom no standard therapy exists;
• Evaluable lesion required for dose escalation phase and at least 1 measurable lesion as per RECIST v1.1 or mRECIST v1.1 required for dose expansion phase;

You may not qualify if…

• Patients who have previously received a TEAD inhibitor;
• Inadequate wash-out of prior therapies described per protocol, which may include anti-tumor therapies, tumor adjuvant drugs, organ or stem cell transplantation，etc；
• Patients with severe or unstable systemic disease, unstable/symptomatic CNS metastasis, meningeal metastasis and spinal cord compression，malignant tumors, cardiac disease, bleeding or embolic disease, infectious disease, conditions affecting drug swallow and absorption, medical history leading to chronic diarrhea, etc;
• Pregnancy or lactation;
• Other conditions considered not appropriate to participate in this trial by the investigators.

Where it is running

• Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (enrolling)
• Affiliated Hospital of Hebei University — Baoding, Hebei, China (enrolling)
• Hunan Cancer Hospital — Changsha, Hunan, China (enrolling)
• Central Hospital Affiliated to Shandong First Medical University — Jinan, Shandong, China (enrolling)
• Tongji Hospital Tongji Medical College of HUST — Wuhan, Hubei, China
• Taizhou Hospital of Zhejiang Province — Taizhou, Zhejiang, China
• China-Japan Union Hospital of Jilin University — Changchun, Jilin, China
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Zhengzhou, China
• Cancer Hospital Chinese Academy of Medical Sciences — Beijing, Beijing Municipality, China
• Shandong Cancer Hospital — Jinan, Shandong, China
• Harbin Medical University Cancer Hospital — Harbin, Heilongjiang, China

Full record on ClinicalTrials.gov

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