A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers
Recruiting now · Phase 2
Conditions studied: Gastrointestinal Cancer
In brief
The purpose of this study is to find the level of aerobic exercise (AT) that is practical, is safe, and has positive effects on the body that may reduce the side effects of therapy. The study will also look at the way the body responds to exercise and whether there are differences in treatment. This will include looking at the highest treatment dose participants receive, how many people stop, delay, or reduce the treatment, and whether additional medication is needed to treat side effects of therapy.
Key facts
- Study ID
- NCT05789485
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 216
- Starts
- 2023-04-28
- Expected to finish
- 2027-04-18
- Last updated by the study team
- 2026-06-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged ≥18 years
- Diagnosed with colorectal or esophago/gastric solid tumors as defined by one of the following:
- Histological confirmation
- As per standard of care imaging
- Scheduled to receive neoadjuvant chemotherapy or chemotherapy for newly diagnosed metastatic disease
- Performing ≤90 minutes of structured moderate-intensity or strenuous-intensity exercise per week, as evaluated by self-report
- Willingness to comply with all study-related procedures
- Cleared for exercise participation as per screening clearance via the Physical Activity Readiness Questionnaire
You may not qualify if…
- Enrollment onto any other lifestyle interventional investigational study, except interventions determined by the PI not to confound study outcomes
- Receiving treatment for any other diagnosis of invasive cancer
- Mental impairment leading to inability to cooperate
- Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation
Where it is running
- Hartford Healthcare Alliance (Data Collection Only) — Hartford, Connecticut, United States (enrolling)
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States (enrolling)
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey, United States (enrolling)
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States (enrolling)
- Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) — Commack, New York, United States (enrolling)
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York, United States (enrolling)
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) — Rockville Centre, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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