Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa

Starting soon

Conditions studied: Retinitis Pigmentosa

In brief

The study will perform to follow-up UC-MSCs and CM transplantation. 18 patients will be called back to be examined after 5 years of UC-MSC and/or CM transplantation.

Key facts

Study ID

NCT05786287

Run by

PT. Prodia Stem Cell Indonesia

People needed

18

Starts

2026-05-01

Expected to finish

2027-09-01

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Visual field defects at the initial examination with Humphrey perimetry are between 25% to 50%
• Willing to sign informed consent as research subjects
• Willing to do the peribulbar injection with mesenchymal stem cells isolated from umbilical cord tissue
• Willing to do visual field checks with Humphrey's perimetry, vision tests with Snellen boards, Optical Coherent Tomography (OCT) examinations, electroretinogram examinations and fill out a quality of life questionnaire

You may not qualify if…

• Pregnant or nursing women
• Positive result of HIV test
• Have a history of eye tumours
• In the immunosuppressive treatment or other drugs that can affect the growth of transplanted stem cells
• Have another eye disease such as diabetic retinopathy, uveitis, cataract, and glaucoma
• Do not come to control according to the schedule determined by the researcher (loss to follow up)

Where it is running

• Jakarta Eye Center Hospital — Jakarta, DKI Jakarta, Indonesia
• Sardjito Hospital — Yogyakarta, Special Region, Indonesia

Full record on ClinicalTrials.gov

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