A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC)
Running, not enrolling · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Advanced Non-Small Cell Lung Cancer
In brief
This study is researching an experimental drug called fianlimab (also called REGN3767), combined with a medication called cemiplimab (also called REGN2810), individually called a "study drug" or collectively called "study drugs". The study is focused on patients who have advanced non-small cell lung cancer (NSCLC). The aim of the study is to see how effective the combination of fianlimab and cemiplimab is in treating advanced NSCLC, in comparison with cemiplimab by itself. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs * How much study drug is in your blood at different times * Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects) * How administering the study drugs might improve your quality of life
Key facts
- Study ID
- NCT05785767
- Run by
- Regeneron Pharmaceuticals
- People needed
- 149
- Starts
- 2023-06-30
- Expected to finish
- 2027-09-28
- Last updated by the study team
- 2026-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Yuma Regional Medical Center — Yuma, Arizona, United States
- Emad Ibrahim, MD, Inc. — Redlands, California, United States
- Eastern CT Hematology and Oncology Associates — Norwich, Connecticut, United States
- Clermont Oncology Center — Clermont, Florida, United States
- Miami Veterans Administration HealthCare System — Miami, Florida, United States
- Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
- Pinellas Hematology and Oncology — St. Petersburg, Florida, United States
- Tallahassee Memorial Healthcare — Tallahassee, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- University of Illinois — Chicago, Illinois, United States
- Mary Bird Perkins Cancer Center — Baton Rouge, Louisiana, United States
- Hattiesburg Clinic — Hattiesburg, Mississippi, United States
- Mercy South — St Louis, Missouri, United States
- St. Vincent Healthcare — Billings, Montana, United States
- New Mexico Cancer Care Alliance — Albuquerque, New Mexico, United States
- Clinical Research Alliance Inc — Westbury, New York, United States
- Gabrail Cancer Center Research — Canton, Ohio, United States
- University of Tennessee Medical Center — Knoxville, Tennessee, United States
- Renovatio Clinical — El Paso, Texas, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- University of Virginia Medical Center — Charlottesville, Virginia, United States
- Bon Secours Cancer Institute Richmond — Midlothian, Virginia, United States
- Macquarie University Health Science Center (MQ Health) — Macquarie Park, New South Wales, Australia
- Riverina Cancer Care Centre (RCCC) — Wagga Wagga, New South Wales, Australia
- Arizona Clinical Research Center — Tucson, Arizona, United States
Full record on ClinicalTrials.gov
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