Plaque Reversal With Early, Aggressive Lipid Lowering Therapy

Recruiting now

Conditions studied: Coronary Artery Disease Progression

In brief

This study evaluates whether plaques in young patients with familial hypercholesterolemia (aged below 50 years) are susceptible to significant plaque regression with early, intensive lipid lowering therapy.

Key facts

Study ID

NCT05783804

Run by

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

People needed

60

Starts

2022-07-07

Expected to finish

2027-04-01

Last updated by the study team

2025-10-02

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with heterozygous familial hypercholesterolemia
• Adult between 18 and 50 years old
• LDL cholesterol levels above 100 mg/dl (>2.6 mmol/L) at inclusion

You may not qualify if…

• Renal insufficiency, defined as eGFR < 30 ml/min
• History of atherosclerotic cardiovascular events
• Atrial fibrillation
• Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
• Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.

Where it is running

• Amsterdam UMC, location AMC — Amsterdam, North Holland, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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