Midwest TXTXT Scale up of an Evidence-Based Intervention to Promote HIV Medication Adherence

Completed · Not applicable

Conditions studied: HIV Infections

In brief

This research study uses a cluster randomized controlled trial design to evaluate the effectiveness of Treatment Text (TXTXT) intervention on adherence and viral load suppression at 3- and 6- months post intervention initiation for youth and young adults with HIV. A total of 12 clinics will be randomized into one of the following two conditions: 1. Comparison Arm (n=6 clinics)- Clinics randomized to the comparison arm will have participants receive the standard of care for 3 months, followed by a 3-month intervention period. 2. Intervention Arm (n=6 clinics)- Clinics randomized to the intervention arm will have participants receive the TXTXT intervention for 6 months.

Key facts

Study ID

NCT05783297

Run by

Amy K. Johnson, PhD, MSW

People needed

210

Starts

2023-04-17

Expected to finish

2025-08-01

Last updated by the study team

2026-06-04

Who can join

Age: 16 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with HIV-infection and on ART regimen for at least one month
• Between 16-35 years of age
• Have a viral load ≥200c/mL and/or report poor adherence (<90% of pills taken in the last 30 days)
• Able to receive text messages
• Can provide informed consent for research component
• Current patient patient of a participating clinic

You may not qualify if…

• Participant is unable to give informed consent
• Participant is participating in another study related to ART adherence
• Participants outside of the age range (16-35) will be excluded from the study because this study specifically focuses on youth and young adults living with HIV as they are more likely to disengage from care, delay initiation of ART, and have lower rates of virologic suppression compared to adult populations.

Where it is running

• AIDS Healthcare Foundation — Fort Lauderdale, Florida, United States
• University of Illinois at Chicago — Chicago, Illinois, United States
• Howard Brown Health — Chicago, Illinois, United States
• Eskenazi Health — Indianapolis, Indiana, United States
• Indiana University — Indianapolis, Indiana, United States
• Comprehensive Care Center of Southwest Louisiana — Lake Charles, Louisiana, United States
• Corktown Health Center — Detroit, Michigan, United States
• KC Care Health Center — Kansas City, Missouri, United States
• Duke University — Durham, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Baylor College of Medicine — Houston, Texas, United States
• Valley AIDS Council — McAllen, Texas, United States

Full record on ClinicalTrials.gov

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