Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones

Stopped early · Not applicable

Conditions studied: Parkinson Disease, Lewy Body Dementia, Parkinson Disease Dementia

In brief

Small exploratory open-label pilot study to assess supplementation of a ketone ester (KetoneAid) as a potential therapy for persons with Parkinson disease (PD), Parkinson Disease Dementia/Lewy Body Dementia (PDD/LBD), and healthy controls.

Key facts

Study ID

NCT05778695

Run by

University of Michigan

People needed

16

Starts

2023-03-09

Expected to finish

2023-10-04

Last updated by the study team

2025-02-12

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy control volunteers over 45 years of age
• People with Parkinson Disease over 45 years of age
• People with Parkinson's Disease Dementia or Lewy Body Dementia over 45 years of age

You may not qualify if…

• Participants with contra-indications to MR imaging, including pacemakers or claustrophobia;
• Evidence of large vessel stroke or mass lesion on MRI
• Regular use of anti-cholinergic, benzodiazepines, high dose (>100mg QD) of quetiapine, or neuroleptic drugs
• History of significant GI disease
• Significant metabolic or uncontrolled medical comorbidity
• Poorly controlled diabetes
• Pregnancy or breast feeding
• Current excessive alcohol use
• Suicidal ideation

Where it is running

• Domino's Farms — Ann Arbor, Michigan, United States
• University Hospital — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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