AV Junction Ablation or Optimal Medical Treatment in PatiEnts With Cardiac Resynchronization Therapy and Permanent Atrial Fibrillation

Recruiting now · Not applicable

Conditions studied: Recurrent Atrial Fibrillation, Persistent Atrial Fibrillation

In brief

A study comparing atrioventricular junction ablation (AVJA) versus continued optimum medical rate control in patients with cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) with suboptimal heart rate control on optimum medication.

Key facts

Study ID

NCT05776797

Run by

University Hospital Ostrava

People needed

480

Starts

2023-04-01

Expected to finish

2029-03-31

Last updated by the study team

2023-06-08

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Treatment with CRT using either a biventricular pacemaker/defibrillator or conduction system pacemaker (>6 months)
• Diagnosis of AF and classified as: permanent AF or recurrent persistent AF, requiring emergency visits and/or hospitalizations (at least one in recent year)
• Optimized HF medical treatment and rate control medication
• BiVP% + ventricular premature complex (VPC%) <99% and >85% during the minimum period of 1 month while already on optimum medical therapy (applicable only for patients with permanent AF)
• Age >18 and <85 years
• Signed informed consent

You may not qualify if…

• myocardial infarction (MI) or coronary artery bypass graft (CABG) <3 months
• Technical failure of the CRT system
• Intentional preference for spontaneous AV conduction
• Expected survival <1 year
• Other significant comorbidities and/or conditions that interfere with the proper conduction of the trial
• Dementia as assessed by mini-mental test (<23 points)

Where it is running

• Regional Hospital Liberec — Liberec, Liberec Region, Czechia (enrolling)
• University Hospital Ostrava — Ostrava, Moravian-Silesian Region, Czechia (enrolling)
• Hospital Podlesí, Inc. — Třinec, Moravian-Silesian Region, Czechia (enrolling)
• University Hospital Olomouc — Olomouc, Olomouc Region, Czechia (enrolling)
• Hospital České Budějovice — České Budějovice, South Bohemian Region, Czechia (enrolling)
• St. Anne's University Hospital Brno — Brno, South Moravian, Czechia (enrolling)
• University Hospital Brno — Brno, South Moravian, Czechia (enrolling)
• Institute of Clinical and Experimental Medicine — Prague, Czechia (enrolling)
• Military University Hospital Prague — Prague, Czechia (enrolling)

Full record on ClinicalTrials.gov

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