Glutamate Excitotoxicity and Its Role in Glioblastoma Biology

Recruiting now

Conditions studied: Brain Tumor, Primary

In brief

Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion

Key facts

Study ID

NCT05775458

Run by

IRCCS San Raffaele

People needed

50

Starts

2020-06-01

Expected to finish

2029-09-30

Last updated by the study team

2025-06-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant).
• Patient able to provide informed consent.

You may not qualify if…

• Age < 18 years
• Liver disease
• Severe anemia (Hb <8mg/dl)
• Pregnancy

Where it is running

• IRCCS San Raffaele Scientific Institute — Milan, Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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