Neural Bases of Social Cognitive Processing in Healthy Individuals
Recruiting now
Conditions studied: Healthy Volunteers
In brief
The goal of this single center non-interventional fMRI and EEG study is to assess the neural bases of social cognitive processing in healthy individuals, and whether/how their responsiveness is modulated by ageing. The main questions it aims to answer are: * are there specific brain regions where individual differences in social cognitive performance reflect well-established metrics of social cogntion such as empathy and mentalizing? * is there a relationship, at the behavioral and neural levels, between ageing-related changes in social cognitive performance and empathy/mentalizing? Healthy participants will be recruited for: * a behavioral assessment including multiple tests of social cognition focused on empathy and mentalizing; * for half participants: a fMRI session to collect data concerning a) brain activity associated with action observation and social cognitive processing, b) brain structural morphometriy (grey-matter volume/density), and c) brain structural connectivity (diffusion weighted imaging) * for half participants: a EEG session to collect data concerning brain responsiveness to social cognitive processing with higher temporal resolution than that afforded by fMRI. Results will provide an useful baseline for investigating alterations of social cognitive processing, and of their neural bases, in pathological conditions.
Key facts
- Study ID
- NCT05774860
- Run by
- Istituti Clinici Scientifici Maugeri SpA
- People needed
- 200
- Starts
- 2018-07-14
- Expected to finish
- 2027-10-31
- Last updated by the study team
- 2026-05-08
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Healthy participants, as determined by screening assessments and principal investigator judgment
- The participant must be able to comply with study requirements as judged by the principal investigator
You may not qualify if…
- Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
- Use of any psychoactive medication, or medications known to have effect on central nervous system (CNS) or blood flow
- Any contraindications for magnetic resonance imaging (MRI) scans or any brain/head abnormalities restricting MRI eligibility
Where it is running
- Istituti Clinici Scientifici Maugeri SpA — Pavia, Ita, Italy (enrolling)
Full record on ClinicalTrials.gov
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