Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic Hypersomnia

Recruiting now · Not applicable

Conditions studied: Narcolepsy, Social Cognition

In brief

Narcolepsy is a chronic disabling neurologic disorder mainly characterised by excessive daytime sleepiness. Type 1 narcolepsy is associated with a deficit of hypocretin in the cerebrospinal fluid responsible for the cataplexy symptom while type 2 shows a normal hypocretin level and no cataplexy. While the development of narcolepsy is independent of parental social level, narcolepsy has a significant influence on educational level, grading, social outcome, and welfare consequences. Several studies assessed global cognition efficiency, mood, and attention in narcoleptic patients but only a few specifically measured social cognition and mostly without a control group. In a population of narcoleptics children, a severe impairment in social cognition is described for 20% of the group, contrary to 2 % for the control group. The literature also depicts some impairments in decision making, somatic and cognitive emotions responses but the emotion recognition seems to be preserved. A better understanding of the social and cognitive aspects of narcolepsy could lead to a better treatment of the disease in its entirety, including if relevant specific cognitive behavioural therapy. The protocol consists in a psychometric evaluation including several questionnaires in order to assess social cognition. It will be proposed to patients with type 1 or type 2 narcolepsy and patients with idiopathic hypersomnia.

Key facts

Study ID

NCT05773872

Run by

Centre Hospitalier Universitaire, Amiens

People needed

75

Starts

2022-11-18

Expected to finish

2027-05-01

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adult patients (>/= 18years old)
• diagnosis of type 1 or type 2 narcolepsy or idiopathic hypersomnia
• non opposition

You may not qualify if…

• comorbid psychiatric or neurologic disease
• patient under 18 years old
• patient under guardianship, curators or deprived of liberty, refusal of the patient

Where it is running

• CHU Amiens-Picardie — Amiens, France (enrolling)

Full record on ClinicalTrials.gov

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