Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans
Completed · Not applicable
Conditions studied: Human Health, Reactive Carbonyl Species, Polyphenols
In brief
This is an interventional study to investigate the formation and pharmacokinetics of reactive carbonyl species adducts of dietary polyphenols (soymilk, green tea, and blueberry) in humans after a single dose of dietary flavonoids.
Key facts
- Study ID
- NCT05773794
- Run by
- North Carolina Agriculture & Technical State University
- People needed
- 48
- Starts
- 2023-02-06
- Expected to finish
- 2023-12-19
- Last updated by the study team
- 2026-06-02
Who can join
Age: 25 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 25-70 years
- BMI between 18 and 30
- Have no known allergy to soy milk
- Be not taking antibiotics for six months
- Be not currently taking medication
- No taking any prescription drugs
- If supplements were taken, flavonoid-enriched supplements (see list below) should be avoided.
- Major brands Notes: All flavonoid-enriched supplements should be avoided. Soy Isoflavones/ tea/blueberry Lipo-Flavonoid Citrus Bioflavonoids Complex Super Flavonoids Super Antioxidants Quercetin Supplement Essential-C and flavonoids Milk Thistle Other flavonoids supplements, including but not limited: Luteolin, Rutin, etc
- No any drugs or supplements within three weeks of the experiment
- Be nonsmoking
- Have no alcoholic intoxication
- No alcoholic addiction
- < 3-4 drinks per week (less than 2 glasses (300 mL) per drink)
- No alcohol within 3 three weeks of the experiment
- Have no extended exposure to industrial wastes
You may not qualify if…
- Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders
- Cancer patients
- Currently diagnosed cancer patients will be excluded;
- Medication free for >2 years could be considered;
Where it is running
- North Carolina Agriculture and Technical State University — Kannapolis, North Carolina, United States
Full record on ClinicalTrials.gov
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